I: Background

Inhalant anesthetic gases (e.g., isoflurane, halothane, sevoflurane, desmoflurane etc.) are halogenated gases that are typically clear, colorless, highly volatile liquids at normal temperature and pressure. Exposure to these substances occurs when vapors escape into the work environment during the anesthetic administration process.

As waste anesthetic gases possess very poor warning properties, odor is not an adequate indication of overexposure. Long-term exposure to waste anesthetic gases has been linked to various health hazards such as genetic mutations, cancers, spontaneous abortions, hepatic and renal disease, and psychomotor changes in humans.  

II: Related Policies and Guidance

• Policy 529-251: Policy on Training of Animal Users

III: Policy

It is the responsibility of the Principal Investigator (PI) to ensure that all laboratory personnel working with inhalant anesthetic gases are properly trained and that the equipment is properly maintained and documented. It is also the PI’s responsibility to ensure the appropriate scavenging systems are in place to reduce exposure to waste anesthetic gases. Laboratory

 

The most common inhalant anesthetic gas used on campus is isoflurane. Investigators using isoflurane are required to read and follow EH&S’s Isoflurane Anesthetic Gas Safety Guidelines.

For all other inhalant anesthetic gases, investigators are to consult with EH&S for guidance on personnel training and proper use and maintenance of equipment.

Approved on: 10/23/1993; Policy 529-304: Inhalational Anesthesia Vaporizer Preventative Maintenance, effective 4/2/2012, was added in the version approved on 8/16/2021, Reviewed on: 07/13/2026