UCR last received an S10 in Federal FY2022.

ORIP continues the Basic Instrumentation Grant (BIG)
Program. The Program targets institutions that have not received a substantial
S10 shared instrumentation award funding of a total of $500,001 or greater in
proceeding 3 Federal FYs.

The BIG Program supports acquisitions of scientific
instruments that are justified by investigators needs to pursue their
scientific projects in basic, translational, or clinical fields. The program
requires that three Major Users with NIH-funded research projects demonstrate
significant need for the requested instrument. Once the requirement of three
Major Users with NIH research funding has been met, additional users may be
included.

The BIG Program provides funds to purchase a single piece of
new, costly, specialized, commercially available instrument or an integrated
instrumentation system. An integrated instrumentation system is one in which
the components, when used in conjunction with one another, perform a function
that no single component can provide. The components must be dedicated to the
system and not used independently. Types of instruments supported include, but
are not limited to, basic cell sorters, confocal microscopes, ultramicrotomes,
gel imagers, or computer systems. Applications for standalone computer systems
(supercomputers, computer clusters, and data storage systems) will only be
considered if the system is solely dedicated to biomedical research. All
instruments, integrated systems, and computer systems must be dedicated to
research only.

Awards: Applications will be accepted that request a single,
commercially available instrument or an integrated instrumentation system. The
minimum award is $25,000. There is no upper limit on the cost of the
instrument, but the maximum award is $350,000. Since the cost of various
instruments will vary, it is anticipated that the amount of the award will also
vary. S10 awards do not allow indirect costs.