This Funding Opportunity Announcement
(FOA) is designed to support highly integrated research teams of three
to six Program Directors/Principal Investigators (PDs/PIs) to address
ambitious and challenging research questions that are within the mission
of NIGMS. Project goals should not be achievable with a collection of
individual efforts or projects. Collaborative program teams are expected
to accomplish goals that require considerable synergy and managed team
interactions. Teams are encouraged to consider far-reaching objectives
that will produce major advances in their fields.

This FOA is not intended for applications that are
mainly focused on the creation, expansion, and/or maintenance of
community resources, creation of new technologies, or infrastructure
development.

NIGMS mission: The National Institute of General Medical Sciences (NIGMS) supports
basic research that increases our understanding of biological processes
and lays the foundation for advances in disease diagnosis, treatment,
and prevention. NIGMS also supports research in specific clinical areas
that affect multiple organ systems: anesthesiology and peri-operative
pain; clinical pharmacology common to multiple drugs and treatments; and
injury, critical illness, sepsis, and wound healing. NIGMS-funded
scientists investigate how living systems work at a range of levels—from
molecules and cells to tissues and organs—in research organisms,
humans, and populations. Additionally, to ensure the vitality and
continued productivity of the research enterprise, NIGMS provides
leadership in supporting the training of future scientists and
developing research capacity throughout the country.

Budget: While applications
may request research program budgets of up to $1.5 million direct costs
per year, it is anticipated that most awards will be between
$700,000-$900,000 direct costs. Annual inflationary increases are not
allowed. The requested budget should be consistent with the number of
PDs/PIs and the complexity and needs of the proposed program. An
additional $250,000 direct costs per year may be requested for optional
developmental funds to support the addition of ESIs to the program in
years 2-5.

Project Period: Up to 5 years.